UNC Lineberger’s Channing Der, PhD, and colleagues have made new findings that could help researchers identify treatments for cancers with mutations in the RAS gene family, which are among the most highly mutated genes in cancer.
Angelina Vaseva Awarded 2017 Women in Cancer Research Scholar Awards
Der Lab postdoc, Angelina Vaseva ,was awarded a 2017 Women in Cancer Research Scholar Award. AACR-WICR Scholar Awards are awarded to members of Women in Cancer Research who are scientists-in-training and presenters of meritorious scientific papers at AACR Annual Meetings. To learn more about these awards visit: http://www.aacr.org/Meetings/Pages/Travel%20Grants/women-in-cancer-research-scholar-awards.aspx#.WRMsslXyvIU
Dr. Der Keynote Speaker at UNC Charlotte 4th Annual Biological Sciences Symposium
On May 4, Dr. Der was the keynote speaker at the 4th Annual Biological Sciences Symposium at UNC Charlotte. This event was sponsored by the Association of Biological Sciences Graduate Students (ABSGS) at the University of North Carolina at Charlotte. Dr. Der's talk was titled "Targeting Ras for cancer treatment: Know your enemy".
UNC’s Running RAScals at PurpleStride 5K
The Running RAScals (aka the Der Lab at UNC Lineberger & Friends) participated in this year’s PanCAN #PurpleStride run on Saturday. This 5k run raises money to support the Pancreatic Cancer Action Network. The team, organized by Kirsten Bryant, raised $12,998 to support Pancreatic Cancer Research, coming in Second in overall fundraising!
Der Lab Participates in Tar Heel 10 Miler
This past Saturday several members of the Der Lab participated in the Tar Heel 10 Miler. The Tar Heel 10 Miler benefits the UNC Lineberger Comprehensive Cancer Center and the Chapel Hill-Carrboro YMCA’s We Build People Campaign. The lab runners included postdocs Kirsten Bryant, Clint Stalnecker, Andrew Waters, and Bjoern Papke, graduate student Nate Diehl, and … Continue reading Der Lab Participates in Tar Heel 10 Miler
Bjoern Papke and Channing J. Der published a review in Science.
In the recently published review “Drugging Ras: Know your enemy” Bjoern Papke and Channing Der summarize the latest efforts in targeting the Ras oncogene. The review was part of the special review series “Frontiers in Cancer Therapy”. http://science.sciencemag.org/content/355/6330/1158
Der presented a plenary lecture at the 36th Annual Conference of Indian Association for Cancer Research
Channing Der presented a plenary lecture at the 36th Annual Conference of Indian Association for Cancer Research on: The 21st Century - War on Cancer, February 9-11, 2017, Amala Cancer Research Centre, Thrissur, Kerala, India.
George and Huynh were authors on a research study that evaluated the role of posttranslational modifications in regulating KRAS oncogene function.
Abstract The KRAS GTPase plays a critical role in control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also by posttranslational modification. Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role this residue in intrinsic KRAS function has not … Continue reading George and Huynh were authors on a research study that evaluated the role of posttranslational modifications in regulating KRAS oncogene function.
Kirsten Bryant authored a review in Cancer Cell, highlighting studies by Bar-Sagi and colleagues published in Cell.
Mutant RAS-driven cancers are infamously resistant to chemotherapeutics. Reporting in Cell, Grabocka and Bar-Sagi (2016) demonstrate that when subjected to stress, mutant KRAS-dependent lipid production leads to upregulated stress granule formation. This confers not only cell-autonomous cytoprotection but also paracrine establishment of a stress-resistant tumor niche. Mutant RAS Calms Stressed-Out Cancer Cells. Bryant KL, Der CJ. Dev Cell. … Continue reading Kirsten Bryant authored a review in Cancer Cell, highlighting studies by Bar-Sagi and colleagues published in Cell.
World Pancreatic Cancer Day
The Der Lab has gone purple for the entire month of November for Pancreatic Cancer Awareness Month! Every day they wear purple they are raising money for the Pancreatic Cancer Action Network. Yesterday, November 17, was World Pancreatic Cancer Day and the lab spent the day showing their support for Pancreatic Cancer Research all day. See … Continue reading World Pancreatic Cancer Day
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