2018

Waters AM, Der CJ. KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer. Cold Spring Harb Perspect Med. 2018;8(9):a031435. Published. doi:10.1101/cshperspect.a031435

Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV (2018). Computational design of chemogenetic and optogenetic split proteinsNat Commun. 2018;9(1):4042. Published 2018 Oct 2. doi:10.1038/s41467-018-06531-4

Lawson, CD, Der, CJ. Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancersSmall GTPases, 2018 Jul 4; 9:4, 290-296, doi: 10.1080/21541248.2016.1220350

Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ. KRAS Suppression-Induced Degradation of MYC is Antagonized by a MEK5-ERK5 Compensatory MechanismCancer Cell, 2018 Nov 12; 34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001.

2017

Waters AM, Ozkan-Dagliyan I, Vaseva AV, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science signaling. 2017;10(498):eaao3332. doi:10.1126/scisignal.aao3332. PMCID: PMC5812265

Anderson GR, Winter PS, Lin KH, et al. A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution. Cell reports. 2017;20(4):999-1015. doi:10.1016/j.celrep.2017.07.006. PMCID: PMC5567854

Stratford JK, Yan F, Hill RA, et al. Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. Freeman J, ed. PLoS ONE. 2017;12(4):e0174863. doi:10.1371/journal.pone.0174863.  PMCID: PMC5381904

Yin G, Kistler S, George SD, et al. A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. The Journal of Biological Chemistry. 2017;292(11):4446-4456. doi:10.1074/jbc.M116.762435. PMCID: PMC5377764

Justilien V, Ali SA, Jamieson L, et al. Ect2-dependent rRNA synthesis is required for KRAS/TP53-driven lung adenocarcinoma. Cancer cell. 2017;31(2):256-269. doi:10.1016/j.ccell.2016.12.010. PMCID: PMC5310966

2016

Lawson CD, Der CJ. Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers. Small GTPases. 2018;9(4):290-296. doi:10.1080/21541248.2016.1220350. PMCID: PMC5997163

Ryan MB, Finn AJ, Pedone KH, Thomas NE, Der CJ, Cox AD. ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-mutant Melanoma. Molecular cancer research : MCR. 2016;14(10):1009-1018. doi:10.1158/1541-7786.MCR-16-0184. PMCID: PMC5065759

Zhou B, Der CJ, Cox AD. The role of wild type RAS isoforms in cancer. Seminars in cell & developmental biology. 2016;58:60-69. doi:10.1016/j.semcdb.2016.07.012.  PMCID: PMC5028303

Lawson CD, Fan C, Mitin N, et al. Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-activating Proteins in Basal-like Breast Cancers. Cancer research. 2016;76(13):3826-3837. doi:10.1158/0008-5472.CAN-15-2923. PMCID: PMC4930678

Zhou B, Ritt DA, Morrison DK, Der CJ, Cox AD. Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. The Journal of Biological Chemistry. 2016;291(34):17804-17815. doi:10.1074/jbc.M115.712885.  PMCID: PMC5016172

Zeitouni D, Pylayeva-Gupta Y, Der CJ, Bryant KL. KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment. Cicenas J, ed. Cancers. 2016;8(4):45. doi:10.3390/cancers8040045. PMCID: PMC4846854
Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. Journal of Cell Science. 2016;129(7):1287-1292. doi:10.1242/jcs.182873.  PMCID: PMC4869631
Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi:10.1080/15548627.2015.1100356. PMCID: PMC4835977
Gentry LR, Karginov AV, Hahn KM, Der CJ. Characterization of an Engineered Src Kinase to Study Src Signaling and Biology. Methods in molecular biology (Clifton, NJ). 2016;1360:157-167. doi:10.1007/978-1-4939-3073-9_12. PMCID: PMC4621786

2015

Hayes TK, Neel NF, Hu C, et al. Long-term ERK Inhibition in KRAS-mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer cell. 2016;29(1):75-89. doi:10.1016/j.ccell.2015.11.011.  PMCID: PMC4816652

Ryan MB, Der CJ, Wang-Gillam A, Cox AD. Targeting RAS-mutant cancers: is ERK the key? Trends in cancer. 2015;1(3):183-198. doi:10.1016/j.trecan.2015.10.001.  PMCID: PMC4743050

Philips MR, Der CJ. Seeing is believing: Ras dimers observed in live cells. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(32):9793-9794. doi:10.1073/pnas.1511805112.  PMCID: PMC4538609

Gentry LR, Nishimura A, Cox AD, et al. Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases. The Journal of Biological Chemistry. 2015;290(37):22851-22861. doi:10.1074/jbc.M115.656710. PMCID: PMC4566255

Kidd AR, Muñiz-Medina V, Der CJ, Cox AD, Reiner DJ. The CelegansChp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.Schweisguth F, ed. PLoS ONE. 2015;10(7):e0133226. doi:10.1371/journal.pone.0133226. PMCID: PMC4514874

Black JL, Harrell JC, Leisner TM, et al. CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. Breast cancer research and treatment. 2015;152(2):337-346. doi:10.1007/s10549-015-3458-4. PMCID: PMC4516161

Cox AD, Der CJ, Philips MR. Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery? Clinical cancer research : an official journal of the American Association for Cancer Research. 2015;21(8):1819-1827. doi:10.1158/1078-0432.CCR-14-3214. PMCID: PMC4400837

2014

Gentry LR, Martin TD, Reiner DJ, Der CJ. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochim Biophys Acta. 2014 Dec;1843(12):2976-2988. doi:10.1016/j.bbamcr.2014.09.004. Epub 2014 Sep 16. Review. PMCID: PMC4201770.

Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission Possible? Nat Rev Drug Discov. 2014 Nov;13(11):828-51. doi: 10.1038/nrd4389. Epub 2014 Oct 17. PMID: 25323927.

Baker NM, Yee Chow H, Chernoff J, Der CJ. Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clin Cancer Res. 2014 Sep 15;20(18):4740-6. doi: 10.1158/1078-0432.CCR-13-1727. PMCID: PMC4166583.

Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep 16. Review. PubMed PMID: 24037532.

Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT. P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J Cell Sci. 2014 Jun 1;127(Pt 11):2589-600. doi: 10.1242/jcs.153049. Epub 2014 Mar 21. PMID: 24659802 [PubMed – in process]

Lawson CD, Burridge K. The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration. Small GTPases. 2014 Mar 7;5. Review. PMCID: PMC4114617

Bryant KL, Mancias JD, Kimmelman AC, Der CJ. KRAS: feeding pancreatic cancer proliferation. Trends Biochem Sci. 2014 Feb;39(2):91-100. doi:10.1016/j.tibs.2013.12.004. Epub 2014 Jan 2. Review. PMCID: PMC3955735.

Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion. Mol Cell. 2014 Jan 23;53(2):209-20. doi:10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2. PMCID: PMC3955741.

Neel NF, Stratford JK, Shinde V, Ecsedy JA, Martin TD, Der CJ, Yeh JJ. Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation. Mol Cancer Ther. 2014 Jan;13(1):122-33. doi: 10.1158/1535-7163.MCT-12-1232. Epub 2013 Nov 12. PMID: 24222664 [PubMed – in process]

2013

Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discov. 2013 Mar;3(3):294-307. doi: 10.1158/2159-8290.CD-12-0198. Epub 2012 Dec 28. PMID: 23274911. PMCID:PMC3595397

Tamanoi F, Der CJ. Inhibitors of the Ras superfamily of small G-proteins. Preface. Enzymes. 2013;34 Pt. B:ix. doi: 10.1016/B978-0-12-420146-0.09985-6. Epub 2013 Nov 7. PMID: 25034107

Kim TY, Jackson S, Xiong Y, Whitsett TG, Lobello JR, Weiss GJ, Tran NL, Bang YJ, Der CJ. CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16868-73. doi: 10.1073/pnas.1306358110.  Epub 2013 Sep 30. PMCID: PMC3801067.

Gentry LR, Martin TD, Der CJ. Mechanisms of targeted therapy resistance take a de-TOR. Cancer Cell. 2013 Sep 9;24(3):284-6. doi: 10.1016/j.ccr.2013.08.021. PMCID: PMC3810955.

Mitin NRossman KL, Currin R, Anne S, Marshall TW, Bear JE, Bautch VL, Der CJ. The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. PLoS One. 2013 Jun 18;8(6):e66260. Print 2013. PMCID: PMC3688894

Baker NMDer CJ. Cancer: Drug for an ‘undruggable’ protein. Nature. 2013 May 30;497(7451):577-8. doi: 10.1038/nature12248. Epub 2013 May 22. PMID: 23698372

Peters EC, Gossett AJ, Goldstein B, Der CJReiner DJ.  Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations. G3 (Bethesda). 2013 Feb;3(2):181-95. doi: 10.1534/g3.112.004416. Epub 2013 Feb 1. PMID: 23390595. PMCID:PMC3564979

Hayes TKDer CJ. Mutant and wild-type Ras: co-conspirators in cancer. Cancer Discov. 2013 Jan;3(1):24-6. doi: 10.1158/2159-8290.CD-12-0521. PMCID: PMC3808242

Gentry L, Samatar AA, b. Inhibitors of the ERK mitogen-activated protein kinase cascade for targeting RAS mutant cancers. Enzymes. 2013;34 Pt. B:67-106. doi: 10.1016/B978-0-12-420146-0.00004-4. Epub 2013 Nov 7. Review. PMID: 25034101

2012

Pedone, K and Der, CJ.  (2012). Small GTPases, in Encyclopedia of Biological Chemistry  (W.J. Lennartz and MD Lane, eds), Elsevier, Oxford, in press.

Sells, J and Der, CJ. (2012) RasGAP. In Encyclopedia of Genetics, 2nd edition (S. Maloy and K. Hughes, eds), Elsevier, Oxford, in press.

Neel, NF, Rossman, KL, Martin, TD, Hayes, TK, Yeh, JJ and Der, CJ. The RalB small GTPase mediates invadopodia formation through a GTPase activating protein-independent function of the RalBP1/RLIP76 effector. Mol Cell Biol. 2012 Apr;32(8):1374-86. doi: 10.1128/MCB.06291-11. Epub 2012 Feb 13. PMID: 22331470. PMCID:PMC3318593

Mitin, N, Roberts, PJ, Chenette, EJ, and Der, CJ. (2012). Posttranslational lipid modification of Rho family small GTPases. In Rho GTPases: Methods and Protocols, Methods in Molecular Biology, Vol. 827:87-95 (Francisco Rivero, ed.), Humana Press. PMID: 22144269

Martin TD, Der CJ. Differential involvement of RalA and RalB in colorectal cancer. Small GTPases. 2012 Apr-Jun;3(2):126-30. doi: 10.4161/sgtp.19571. PMID: 22790202. PMCID:PMC3408977

Cox, A.D. and Der, C.J. The Raf inhibitor paradox revisited.  Cancer Cell. 2012 Feb 14;21(2):147-9. doi: 10.1016/j.ccr.2012.01.017. PMID: 22340588. PMCID:PMC3285264

Martin, TD, Mitin, N, Cox, AD, Yeh, JJ, Der, CD. (2012) Phosphorylation by protein kinase C alpha regulates RalB small GTPase activation, subcellular localization, and effector utilization. J Biol Chem. 2012 Apr 27;287(18):14827-36. doi: 10.1074/jbc.M112.344986. Epub 2012 Mar 5. PMID: 22393054. PMCID:PMC3340265

Mitin N, Rossman KL, Der CJ. Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4. PLoS One. 2012;7(7):e41876. Epub 2012 Jul 24. PMID:22911862. PMCID:PMC3404065

Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion.Cancer Res. 2012 Oct 15;72(20):5338-47. doi: 10.1158/0008-5472.CAN-11-2373. Epub 2012 Aug 31. PMID: 22942252. PMCID:PMC3810962

Congratulations to Danielle Cook for her stunning cover image in Genes & Cancer, October, 2011

Martin, T.D., Samuel, J.C., Routh, E.D., Der, C.J. and Yeh, J.J.  (2011). Activation and involvement of Ral GTPases in colorectal cancer.  Cancer Res., 71:206-215.

Justilien, V., Jameison, L., Der, C.J., Rossman, K.L., Fields, A.P. (2011). The oncogenic activity of ECT2 is regulated through protein kinase Ci mediated phosphorylation. J. Biol. Chem., 286, 8149-8157.

Zand, T.P., Reiner, D.J. and Der, C.J. (2011). Ras effector switching promotes divergent cell fates in C. elegans vulva patterning.  Dev. Cell, 20:84-96.

Stevens, E.V., Banet, N., Onesto, C., Plachco, A., Alan, J.K., Nikolaishvili-Feinberg, N., Midkiff, B.R., Kuan,P.F., Liu,J., Miller, C.R., Vigil, D., Graves, L.M., and Der, C.J. (2011) RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis.  Small GTPases. 2011 Jul;2(4):202-210.

Lindsay, C.R., Lawn, S., Campbell, A.D., Faller, W.J., Rambow, F., Mort, R.L., Timpson, P., Li, A., Cammareri, P., Ridgway, R.A., Morton, J.P., Doyle, B., Hegarty, S., Rafferty, M., Murphy, I.G., McDermott, E.W., Sheahan, K, Pedone, K, Finn, A.J., Groben, P.A., Thomas, N.E., Hao, H., Carson, C., Norman, J.C., Machesky, L.M., Gallagher, W.M., Jackson, I.J., Van Kempen, L., Beermann, F, Der, C.J., Larue, L., Welch, H.C., Ozanne, B.W. and Sansom, O.J. (2011). P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun. 2011. 2:555. doi: 10.1038/ncomms1560.

Chenette, E. J. and Der, C.J. (2011). Lipid Modification of Ras Superfamily GTPases: Not Just Membrane Glue. In The Enzymes, Vol. 29, Protein Prenylation Part A (F. Tamanoi, C. Hrycyna and M. Bergo, eds), Academic Press, Chapter 5, pp 59-95.

Baines, A.T., Xu, D., Der, C.J. Inhibition of Ras for cancer treatment: the search continues. 2011. Future Med. Chem. Oct 3 (14): 1787-808. PMID:22004085

Cook, DR, Solski, PA, Bultman, SJ, Kauselmann, G, Schoor, M, Kuehn, R, Friedman, LS, Cowley, DO, Van Dyke, T, Yeh, JJ, Johnson, L and Der, CJ. (2012). The Ect2 Rho guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Genes Cancer. 2011 Oct;2(10):932-42. doi: 10.1177/1947601912437035. PMID: 22701760

2010

Lim, K.H., Brady, D.C., Kashatus, D.F., Ancrile, B.B., Der, C.J., Cox, A.D., and Counter, C.M. (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol., 30, 508-523. PMCID:PMC2798468

Gonzalez-Perez, V., Reiner, D.J., Alan, J.K., Mitchell, C., Edwards, L.J., Khazak, V., Der, C.J. and Cox, A.D. (2010) Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. J Mol Signal, 23;5:2. PMCID:PMC2848644

Stevens, E.V., Wells, A., Shin, J. H., Liu, J., Der, C.J. and Schoenfisch, M.H. (2010) Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth. Mol. Pharmaceutics, 7:775-785. PMCID:PMC3569608

Kidd, A.R., 3rd, Snider, J.L., Martin, T.D., Graboski, S.F., Der, C.J., Cox, A.D. (2010). Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation. Int J Radiat Oncol Biol Phys., 78:205-212. PMCID:PMC2922474

Vigil, D., Williams, F., Yeh, J.J., Campbell, S.L. and Der, C.J. (2010). Aberrant overexpression of the RGL2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth. J. Biol. Chem., 285:34729-34740. PMCID:PMC2966088

Stratford, J.K., Bentrem, D.J. , Anderson, J.M., Volmar, K.A., Marron, J.S., Fan, C., Routh, E.D., Caskey, L.S., Samuel, J.C., Der, C.J., Thorne, L.B., Calvo, B.F., Kim, H.J., Talamonti, M.S., Iacobuzio-Donahue, C.A., Hollingsworth, M.A., Perou, C.M., Yeh, J.J. (2010). A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. PLoS Medicine, 7(7):e1000307. PMCID:PMC2903589

Singh, A., Boyer JL, Der CJ, Zohn IE. (2010). Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways. J Mol Signal., 5:11. PMCID:PMC2917412

Campbell, P.M., Boufaied, N., James J Fiordali, J.J., Cox, A.D., Falardeau, P., Der, C.J. and Gourdeau, H. (2010). TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal., 71:206-215. PMCID:PMC2990749

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s