2000’s

2009

Yeh, J.J., Routh, E.D., Rubinas, T., Peacock, J., Martin, T.D., Shen, X.J., Sandler, R.S., Kim, H.J., Keku, T.O. Der, C.J. (2009). KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol Cancer Ther., 8, 834-843. PMCID:PMC2729756

Yang, X. Y., Guan, M., Vigil, D., Der, C.J., Lowy, D.R., Popescu. C. (2009). P120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth suppressing activities. Oncogene, 28, 1401-1409. PMCID:PMC2715999

Matsuo, Y., Campbell, P.M., Brekken, R.A., Sung, B., Ouellette, M.M., Fleming, J.B., Aggarwal, B.B., Der, C.J. and Guha, S. (2009). K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through MAP kinase signaling pathways. Mol. Cancer Res., 7, 799-808. PMID:19509115

Cha, J.Y, Maddileti, S., Mitin, N. Harden, T.K., and Der, C.J. (2009). Aberrant receptor internalization and enhanced FRS2-dependent signaling contributes to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. J. Biol. Chem., 284, 6227-6240. PMCID:PMC2649112

Willard, F.S., Willard, M.D., Kimple, A.J., Soundararajan, M.,Oestreich, E.A., Li, X., Sowa, N.A., Kimple, R.J., Doyle, D.A., Der, C.J., Zylka, M.J., Snider, W.D., and Siderovski, D.P. (2009). Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PLoS ONE, 4, e4884. PMCID:PMC2655719

Hanker, A.B., Healy, K.D., Nichols, J. and Der, C.J. (2009). Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition. J Mol Signal.16, 4:5. PMCID:PMC2735739

Hanker, A.B., Mitin, N., Wilder, R.S., Henske, E.P., Tamanoi, F., Cox, A.D. and Der, C.J.(2009). Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene, 29, 380-391. PMCID:PMC2809798

Madigan, J.P., Bodemann, B.O., Brady, D.C., Dewar, B.J., Keller, P.J., Leitges, M., Philips, M.R., Ridley, A.J., Der, C.J. and Cox, A.D. (2009). Regulation of RND3 localization and function by PKCα-mediated phosphorylation. Biochem. J., 424,153-161. PMCID:PMC2868966

2008

Cha, J.Y., Lambert, Q.T., Reuther, G.W. and Der, C.J. (2008). Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis. Mol. Cancer Res., 6, 435-445. PMID:18337450

Healy, K.D., Shutes, A., Kim, T.H., Juliano, R.L., Bang, Y.-J. and Der, C.J. (2008). DLC-1 suppressions non-small cell lung carcinoma growth and invasion by RhoGAP-dependent and independent mechanisms. Mol. Carcinogenesis, 47, 326-337. PMCID:PMC2679972

Roberts, P.J., Mitin N, Keller, P.J., Chenette, E.J., Madigan, J.P., Currin, R.O., Cox, A.D., Wilson, O., Kirschmeier, P., Der, C.J. (2008). RHO family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J. Biol. Chem., 283, 25150-25163. PMCID:PMC2533093

Kim, T.Y., Healy, K.D., Der, C.J., Sciaky, N., Bang, Y.J., Juliano, R.L. (2008). Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J. Biol. Chem., 283, 32762-32770. PMCID:PMC2583296

2007

Campbell, P.M., Groehler, A.L., Lee, K.M., Ouellette, M.M., Khazak, V. and Der, C.J. (2007). K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res, 67, 2098-2106.

Shields, J.M., Thomas, N.E., Cregger, M., Berger, A.J., Leslie, M., Torrice, C., Hao, H., Penland, S., Arbiser, J., Scott, G., Zhou, T., Bar-Eli, M., Bear, J.E., Der, C.J., Kaufmann, W., Rimm, D.L. and Sharpless, N.E. (2007). Lack of ERK mitogen-activated protein kinase activation and signaling demonstrates a new type of melanoma. Cancer Res, 67, 1502-1512.

Hao, H., Muniz-Medina, V.M., Mehta, H., Thomas, N.E., Klazak, V., Der, C.J. and Shields, J.M. (2007). Differential roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Mol. Cancer Res., 6, 2220-2229.

Repasky, G.A., Zhou, Y., Morita, S. and Der, C.J. (2007). Ras activation of Raf-dependent and Raf-independent signaling causes cyclooxygenase-2-mediated prostaglandin E2 signaling required for intestinal epithelial cell transformation. Mol Carcinogenesis, 46,958-970.

Shutes, A., Onesto, C., Picard, V., Schweighoffer, F. and Der, C.J. (2007). Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J. Biol. Chem., 282, 35666-35678.

Yohe, M.E., Rossman, K.L., Gardner, O.S., Karnoub, A.E., Snyder, J.T., Gershburg, S., Graves, L.M., Der, C.J. and Sondek, J. (2007). Auto-inhibition of the Dbl-family protein Tim by an N-terminal helical motif. J. Biol. Chem., 282, 13813-13823.

Mitin, N., Betts, L., Yohe, M., Sondek, J., Der, C.J. and Rossman, K.L. Release of auto-inhibition of Asef by APC leads to Cdc42 activation and tumor suppression. (2007). Nature Struct. Mol. Biol., 14, 814-823.

Falsetti, S.C., Wang, D.A., Peng, H., Carrico, D., Cox, A.D., Der, C.J., Hamilton, A.D., Sebti, S.M. (2007). Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol. Cell. Biol. 27, 8003-8014.

2006

Chenette, E.J., Mitin, N.Y. and Der, C.J. (2006). Multiple sequence elements facilitate Chp Rho GTPase subcellular localization, membrane association and transforming activity. Mol Biol Cell, 17, 3108-3121.

Kelly, P., Moeller, B.J., Juneja, J., Booden, M.A., Der, C.J., Daaka, Y., Dewhirst, M.W., Fields, T.A. and Casey, P.J. (2006). The G12 family of heterotrimeric G proteins promotes cancer invasion and metastasis. Proc Natl Acad Sci USA, 103, 8173-8178.

Loomis, R.J., Holmes, D.A., Elms, A., Solski, P.A., Der, C.J. and Su, L. (2006). Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis. Traffic, 7, 1643-1653.

Lim, K.H., O’Hayer, K., Adams, S.J., Kendall, S.D., Campbell, P.M., Der, C.J. and Counter, C.M. (2006). Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol, 16, 2385-2394.

Ongusaha, P.P., Kim, H.G., Boswell, S.A., Ridley, A.J., Der, C.J., Dotto, G.P., Kim, Y.B., Aaronson, S.A. and Lee, S.W. (2006). Curr Biol, 16, 2466-2472.

2005

Chenette, E.J., Abo, A. and Der, C.J. (2005). Critical and distinct roles of amino and carboxyl terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. J Biol Chem, 280, 13784-13792.

Pruitt, K., Ülkü , A.S., Frantz, K., Rojas, R.J., Muniz-Medina, V.M., Rangnekar, V.M., Der, C.J. and Shields, J.M. (2005). Ras mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. J Biol Chem, 280, 23363-23370

Lim, K.H., Baines, A.T., Fiordalisi, J.J., Shipitsin, M., Feig, L.A., Cox, A.D., Der, C.J. and Counter, C.M. (2005). Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell, 7, 533-545.

Brian C. Capell, Michael R. Erdos, James P. Madigan, James J. Fiordalisi, Renee Varga, Karen N. Conneely, Leslie B. Gordon, Channing J. Der, Adrienne D. Cox, and Francis S. Collins. (2005). Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA, 36, 12879-12884.

Berzat, A.C., Buss, J.E., Chenette, E.J., Weinbaum, C.A., Shutes, A., Der, C.J., Minden, A. and Cox, A.D. (2005). Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. J. Biol. Chem., 280, 33055-33065.

2004

Booden, M.A, Eckert, L.B, Der, C.J, and Trejo, J. (2004). Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Mol Cell Biol, 24, 1990-1999.

Fuentes, E.J., Der, C.J., Lee, A.L. Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. (2004). J Mol Biol, 335, 1105-1115.

Aitsebaomo, J., Wennerberg, K., Der, C.J., Zhang, C., Kedar, V, Moser, M., Kingsley-Kallesen, M.L., Zeng, G.Q., and Patterson, C. (2004). p68RacGAP is a novel GTPase-activating protein that interacts with Vezf1 and modulates endothelial cell capillary formation. J Biol Chem, 279, 17963-17972.

Mitin, N., Ramocki, M.B., Zullo, A.J., Der, C.J., Konieczny, S.F., and Taparowsky, E.J. (2004). Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem, 279, 22353-22361.

Solski, P.A., Wilder, R.S., Rossman, K.L., Sondek, J., Cox, A.D., Campbell, S.L. and Der, C.J. (2004). Requirement for carboxyl-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. J Biol Chem, 279, 25226-25233.

Ellerbroek, S.M., Wennerberg, K., Arthur, W.T., Dunty, J.M., Bowman, D.R., DeMali, K.A., Der, C. and Burridge K. (2004). SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell, 15, 3309-3319.

Collette, J., Ulku, A.S., Der C.J., Jones, A.S., Siddiqui, M. and Erickson,.A.H. (2004). Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells. Int J Cancer, 112, 190-199.

Eckert, L.B., Ulku, A.S., Repasky, G.A., McFall, A., Zhou, H., Sartor, C.I. and Der, C.J. (2004). Activation of Ras and HER2 signaling pathways in human breast cancer cells and their role in anoikis. Cancer Res, 64, 4582-4592.

Huntington, J.T., Shields, J.M., Der, C.J., Wyatt, C.A., Benbow, U., Slingluff, C.L. Jr, Brinckerhoff, C.E. (2004). Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: Role of BRAF mutation and FGF signaling. J Biol Chem, 279, 33186-33176.

Singh, A., Karnoub, A.E., Palmby, T., Lengeyl, E., Sondek, J. and Der, C.J. (2004). Rac1b, a novel tumor-associated Rac1 splice variant, promotes cellular transformation via non-cononical Rac1 signaling pathways. Oncogene, 23, 9369-9380.

Shutes, A., Berzat, A., Cox, A.D. and Der, C.J. (2004). Atypical regulation of the Wrch-1 Rho family small GTPase. Curr Biol, 14, 2052-2056.

Zhang, L., Zhang, J., Lambert, Q., Der, C.J., Del Valle, L., Miklossy, J., Khalili, K., Zhou, Y. and Pagano, J.S. (2004). Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties. J Virol, 78, 12987-12995.

Palmby, T.R., Abe, K., Karnoub, A.E. and Der, C.J. (2004). Vav transformation requires activation of multiple GTPases and regulation of gene expression. Mol Cancer Res, 2, 702-711.

2003

Fuentes, E.J., Karnoub, A.E., Booden, M.A., Der, C.J., Campbell, S.L. (2003). Critical role of the pleckstrin homology domain Dbs signaling and growth regulation. J Biol Chem, 278, 21188-21196.

Pruitt, W.M., Karnoub, A.E., Rakauskas, A.C., Guipponi, M., Antonarakis, S.E., Kurakin, A, Kay BK, Sondek J, Siderovski, D.P., and Der, C.J. (2003). Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling. Biochim Biophys Acta, 1640, 61-68.

Wennerberg, K., Forget, M.A., Ellerbroek, S.M., Arthur, W.T., Burridge, K., Settleman, J., Der, C.J., and Hansen, S.H. (2003). Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol, 13, 1106-1115.

Bai, X., Cerimele, F., Ushio-Fukai, M., Waqas, M., Campbell, P., Govindarajan, B., Der, C., Battle, T., Frank, D.A., Ye, K., Murad, E., Dubiel, W., Soff, G., and Arbiser, J.L. (2003). Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem, 278, 35501-35507.

Ulku, A.S., Schafer, R., and Der, C.J. (2003). Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells. Mol Cancer Res, 1, 1077-1088.

Wozniak, M.A., Desai, R., Solski, P.A., Der, C.J., and Keely, P.J. (2003). ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol, 163, 583-595.

2002

Hanker, A.B., Mitin, N., Wilder, R.S., Henske, E.P., Tamanoi, F., Cox, A.D. and Der, C.J. (2009). Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene, 29, 380-391. PMCID:PMC2809798