Abstract The KRAS GTPase plays a critical role in control of cellular growth. The activity of KRAS is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also by posttranslational modification. Lysine 104 in KRAS can be modified by ubiquitylation and acetylation, but the role this residue in intrinsic KRAS function has not … Continue reading George and Huynh were authors on a research study that evaluated the role of posttranslational modifications in regulating KRAS oncogene function.
Der Lab 